The Detroit Lions’ strong 4–1 start to the 2025 NFL season has been overshadowed by a growing list of injuries — none more concerning than the one to star wide receiver Amon-Ra St. Brown. The two-time All-Pro missed Wednesday’s practice with a wrist injury, putting his status for Sunday night’s matchup against the Kansas City Chiefs in doubt.

According to the team’s official injury report, St. Brown is dealing with wrist discomfort after landing awkwardly on his shoulder during last week’s 37–24 win over the Cincinnati Bengals. Despite the hit, he still led the Lions with eight catches for 100 yards. The play, however, may have caused or worsened his current issue heading into Week 6.

So far this season, St. Brown has been the heartbeat of Detroit’s offense, totaling 35 receptions for 407 yards and an NFL-best six touchdowns. He ranks among the league’s top five in both receptions and receiving yards, serving as quarterback Jared Goff’s most dependable target. Goff’s league-leading 75.2% completion rate has heavily depended on St. Brown’s consistency and precision.

Known for his toughness, St. Brown has surpassed 100 catches and 1,100 yards in each of the past three seasons, missing only two games since entering the league. He’s even played through illness before, once battling Hand, Foot, and Mouth disease in 2023. Still, Detroit is expected to be cautious with his wrist, knowing how critical it is to his catching ability.

The Lions have not shared details about the injury, but the timing is challenging for a roster already depleted by other ailments. Cornerbacks D.J. Reed and Terrion Arnold, left tackle Taylor Decker, safety Kerby Joseph, linebacker Zach Cunningham, and running back Sione Vaki all sat out practice on Wednesday. Defensive back Brian Branch, who suffered an ankle tweak last Sunday, was limited.

If St. Brown can’t go, Detroit’s offense will need to adjust quickly. Jameson Williams has yet to find consistency, logging two or fewer receptions in four consecutive games. Without their top playmaker, the Lions could struggle to sustain their explosive passing attack against a Kansas City defense led by First-Team All-Pro corner Trent McDuffie.