The NFL finally returns to action tonight as the Detroit Lions square off against the Los Angeles Chargers. Fans can catch the Hall of Fame game live at 7 p.m. ET on NBC/Peacock.

Although the first preseason matchup isn’t exactly must-see television, it signals that real football is right around the corner. Casual fans might only watch the opening minutes, but here are five key storylines worth keeping an eye on tonight.

Will Isaac TeSlaa Provide a Spark?

Detroit led the league in scoring last year, but still added wide receiver Isaac TeSlaa in the third round of the 2025 Draft. While TeSlaa is expected to make the roster, it’s unclear how large a role he’ll play behind Amon-Ra St. Brown, Jameson Williams, Tim Patrick, and Kalif Raymond. His performance tonight could offer an early indication.

Tyleik Williams: Too Much to Handle?

Hoping to add power to their defensive front, the Lions selected Ohio State’s Tyleik Williams with the 28th overall pick. Measuring 6-foot-3 and 327 pounds, he’s got NFL size. As a first-rounder, he should be dominant in preseason play. Tonight’s game will help determine how ready he really is.

Can Tre’ Harris Impress Early?

Have the Chargers fully reshaped their wide receiver room? Keenan Allen and Mike Williams are both gone, with the latter out of the league. In their place: Ladd McConkey, Quentin Johnston, and rookie Tre’ Harris. Known for his quick feet, Harris is projected to make an early impact. We’ll see how fast he plays tonight.

Trey Lance: Sleeper or Setback?

Trey Lance was the third overall pick in 2021, but has just five starts and 12 games over four years. He’ll start tonight’s Hall of Fame game, hoping to prove he still has upside. Lance was drafted for his athleticism—will that be on display tonight, or will familiar flaws return?

Can Omarion Hampton Steal the Spotlight?

The Chargers’ backfield looks strong with Najee Harris, who’s topped 1,000 rushing yards every season. But rookie Omarion Hampton offers more explosiveness and power through contact. If he shines tonight, Hampton might challenge Harris for the starting job by year’s end.