Josh Allen threw for two touchdowns and ran for two more, leading the Buffalo Bills to a 48-42 victory over the Detroit Lions, ending Detroit’s franchise-record 11-game winning streak.

Allen, who has 10 total touchdowns in two games, passed for 362 yards and rushed for 68. James Cook added 105 rushing yards and two touchdowns for the Bills (11-3).

Jared Goff threw for 494 yards and tied his career high with five touchdown passes for the Lions (12-2), while Amon-Ra St. Brown set career highs with 14 catches and 193 yards, including a touchdown.

The Lions are now tied with the Philadelphia Eagles and Minnesota Vikings for the NFC’s best record, with the Vikings playing the Chicago Bears on Monday night.

Patrick Mahomes passed for two touchdowns before injuring his ankle in the Kansas City Chiefs’ 21-7 win over the Cleveland Browns.

Mahomes completed 19 of 38 passes for 159 yards but was replaced by Carson Wentz after being injured.

Chiefs coach Andy Reid denied Mahomes’ request to return to the game. Kansas City (13-1) had already built its lead, while the Browns (3-11) benched Jameis Winston, who had three interceptions, for Dorian Thompson-Robinson.

Nick Chubb broke his foot, and Jerome Ford’s 62-yard touchdown was Cleveland’s lone highlight.

CJ Stroud threw two touchdown passes to Nico Collins as the Houston Texans clinched the AFC South title with a 20-12 victory over the Miami Dolphins.

Will Anderson Jr. forced a key fumble, Derek Stingley Jr. recorded two interceptions, and Calen Bullock added another for Houston (9-5), which officially secured the division when the Indianapolis Colts lost later in the day.

Tua Tagovailoa completed 29 of 40 passes for 196 yards and a touchdown but tied his career worst with three interceptions for Miami (6-8), now two games out in the AFC wild-card race.

Jalen Hurts passed for two touchdowns and rushed for another as the Philadelphia Eagles beat the Pittsburgh Steelers 27-13 for their 10th straight win.

Playing with a reportedly broken finger on his non-throwing hand, Hurts completed 25 of 32 passes for 290 yards, throwing touchdowns to AJ Brown and DeVonta Smith.

Brown had eight catches for 110 yards as the Eagles (12-2) overcame recent controversy surrounding Hurts and Brown’s relationship.

Pittsburgh (10-4) lost its 11th straight road game in this rivalry but secured a playoff berth with losses by the Dolphins and Colts.

Breece Hall’s one-yard touchdown with 1:05 left lifted the New York Jets to a 32-25 comeback win over the Jacksonville Jaguars.

The game-winning drive included two key Aaron Rodgers-to-Davante Adams connections for gains of 23 and 41 yards.

Cooper Rush threw three touchdown passes, including two in the third quarter, as the Dallas Cowboys pulled away for a 30-14 win over the Carolina Panthers in Charlotte.

Jayden Daniels threw two touchdown passes to Terry McLaurin as the Washington Commanders edged the New Orleans Saints 20-19.

The Saints scored as time expired but failed on a two-point conversion attempt.

Lamar Jackson tied his career high with five touchdown passes, including two to Rashod Bateman, in the Baltimore Ravens’ 35-14 win over the New York Giants.

Joe Burrow threw three touchdown passes, and the Cincinnati Bengals capitalized on four turnovers by Tennessee Titans quarterback Will Levis to win 37-27 in Nashville.

James Conner rushed for 110 yards and two scores, keeping the Arizona Cardinals in the NFC West race with a 30-17 victory over the New England Patriots in Glendale.

The Denver Broncos shut out the Indianapolis Colts in the second half, forcing five turnovers and scoring a defensive touchdown in a 31-13 win.

Mike Evans scored two second-half touchdowns as the Tampa Bay Buccaneers cruised to a 40-17 rout of the Los Angeles Chargers in California.