After conceding 48 points to the Buffalo Bills in their second loss of the season, the Detroit Lions could face more bad news for their defense.

The Lions endured a series of potentially serious injuries during the 48-42 loss on Sunday, with head coach Dan Campbell mentioning after the game that three key players might be done for the season.

This comes amid a string of other defensive injuries for the Lions, making the final three games of the season even more crucial.

Lions Could Lose Two Players

As reporter Tim Twentyman shared after the game, Campbell expressed concern over two players who were injured during the game.

“Dan Campbell said he doesn’t feel good about injuries to Alim McNeill and Carlton Davis III. Thinks they could be season-ending,” Twentyman wrote in a post on X.

McNeill suffered a knee injury and was ruled out, while Davis was lost with a jaw injury early in the second half. Cornerback Khalil Dorsey also appeared to suffer a fractured leg, meaning three key defensive players could be out for the season.

Campbell said the team would learn more after the players underwent testing on Monday, but his tone was grim when talking to reporters.

“Normally if I’m like saying I don’t feel good, that means it’s not good for the rest of the year,” Campbell said, via ESPN. “So, I don’t feel good about it.”

There might be little suspense with Dorsey. The cornerback collided with teammate Ezekiel Turner in the second quarter and seemed to suffer a leg fracture. He was surrounded by teammates on the field before being carted off.

The Lions have faced numerous injuries this season, including leading edge rusher Aidan Hutchinson, who suffered a brutal leg fracture in a win over the Dallas Cowboys. The team has 13 defensive players on injured reserve, though Campbell said Hutchinson could return if the team reaches the Super Bowl.

Loss Hurts Playoff Hopes

Before Sunday’s game, the Lions held a one-game lead over the Philadelphia Eagles for the top NFC seed, but the teams ended the day tied after the Lions’ loss and an Eagles win over the Pittsburgh Steelers.

The Lions lost despite scoring 42 points in what became the highest-scoring NFL game of the season. Campbell took responsibility after the game, admitting his team wasn’t ready to compete with the AFC contender.

“Now we know where we stand against one of the AFC’s best teams,” Campbell said, via ESPN. “Today, that wasn’t good enough.”

The loss also prevented the Lions from making up vital ground in the NFC North. The Minnesota Vikings, who have won six straight games, moved to 11-2 and could tie with the Lions if they defeat the Chicago Bears on Monday night.